Lung cancer risk and talc not containing asbestiform fibres: a review of the epidemiological evidence.
نویسنده
چکیده
A literature search was done and all epidemiological cancer studies mentioning talc as a risk factor were selected. The talc exposed populations were divided into three groups: (1) populations in which no other occupational carcinogen was mentioned (only talc millers satisfied this criterion); (2) populations of talc miners exposed to talc, quartz, and/or radon; and (3) other industrial populations in which talc is associated with quartz, nitrosamines, and asbestos depending on the study. No excess lung cancer mortality was found for the populations of talc millers exposed to high levels of talc but without any other potential carcinogen (SMR = 0.92, 42 cases) while the summary of mortality of talc miners exposed to quartz and/or radon was in excess (fixed effect SMR = 1.20, random effect RR = 1.85, 40 cases). Six studies in other industrial settings were identified. All reported increased lung cancer mortality among talc exposed workers but the talc exposure was confounded with other carcinogens and only one study was able to adjust on them. In conclusion, no increased lung cancer mortality was observed among talc millers despite their high exposure experience. In populations in which talc was associated with other potential carcinogens, some lung cancer excesses were observed.
منابع مشابه
TALe NOT eONTAINING ASBESTIFORM FIBRES (Group 3) and TALe eONTAINING ASBESTIFORM FIBRES (Group 1) A. Evidence for carcinogenicity to humans (inadequate for talc not containing asbestiform
A proportionate mortality study of miners and milers of talc containing asbestiform tremolite has shown an excess of lung cancer and one case of mesothelioma. Another cohort study ofworkers mining and milling talc containing tremolite, anthophyllite and serpentine mineraIs revealed significant excess mortality from lung cancer and from nonmalignant respiratory disease. Mortality from lung cance...
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ورودعنوان ژورنال:
- Occupational and environmental medicine
دوره 63 1 شماره
صفحات -
تاریخ انتشار 2006